Klepac-CerajLemonMartinEtAl2010

Reference

Klepac-Ceraj, V., Lemon, K.P., Martin, T.R., Allgaier, M., Kembel, S.W., Knapp, A.A., Lory, S., Brodie, E.L., Lynch, S.V., Bohannan, B.J.M., Green, J.L., Maurer, B.A., Kolter, R. (2010) Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa. Environmental Microbiology, 12(5):1293-1303. (Scopus )

Abstract

Polymicrobial bronchopulmonary infections in cystic fibrosis (CF) cause progressive lung damage and death. Although the arrival of Pseudomonas aeruginosa often heralds a more rapid rate of pulmonary decline, there is significant inter-individual variation in the rate of decline, the causes of which remain poorly understood. By coupling culture-independent methods with ecological analyses, we discovered correlations between bacterial community profiles and clinical disease markers in respiratory tracts of 45 children with CF. Bacterial community complexity was inversely correlated with patient age, presence of P. aeruginosa and antibiotic exposure, and was related to CF genotype. Strikingly, bacterial communities lacking P. aeruginosa were much more similar to each other than were those containing P. aeruginosa, regardless of antibiotic exposure. This suggests that community composition might be a better predictor of disease progression than the presence of P. aeruginosa alone and deserves further study. © 2010 Society for Applied Microbiology and Blackwell Publishing Ltd.

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@ARTICLE { Klepac-CerajLemonMartinEtAl2010,
    AUTHOR = { Klepac-Ceraj, V. and Lemon, K.P. and Martin, T.R. and Allgaier, M. and Kembel, S.W. and Knapp, A.A. and Lory, S. and Brodie, E.L. and Lynch, S.V. and Bohannan, B.J.M. and Green, J.L. and Maurer, B.A. and Kolter, R. },
    TITLE = { Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa },
    JOURNAL = { Environmental Microbiology },
    YEAR = { 2010 },
    VOLUME = { 12 },
    PAGES = { 1293-1303 },
    NUMBER = { 5 },
    ABSTRACT = { Polymicrobial bronchopulmonary infections in cystic fibrosis (CF) cause progressive lung damage and death. Although the arrival of Pseudomonas aeruginosa often heralds a more rapid rate of pulmonary decline, there is significant inter-individual variation in the rate of decline, the causes of which remain poorly understood. By coupling culture-independent methods with ecological analyses, we discovered correlations between bacterial community profiles and clinical disease markers in respiratory tracts of 45 children with CF. Bacterial community complexity was inversely correlated with patient age, presence of P. aeruginosa and antibiotic exposure, and was related to CF genotype. Strikingly, bacterial communities lacking P. aeruginosa were much more similar to each other than were those containing P. aeruginosa, regardless of antibiotic exposure. This suggests that community composition might be a better predictor of disease progression than the presence of P. aeruginosa alone and deserves further study. © 2010 Society for Applied Microbiology and Blackwell Publishing Ltd. },
    COMMENT = { Cited By (since 1996): 35 Export Date: 17 September 2012 Source: Scopus CODEN: ENMIF doi: 10.1111/j.1462-2920.2010.02173.x },
    ISSN = { 14622912 (ISSN) },
    KEYWORDS = { antiinfective agent, transmembrane conductance regulator, adolescent, age, article, bacterium, child, classification, cystic fibrosis, drug effect, ecosystem, genetics, genotype, human, isolation and purification, lung, microbiology, oropharynx, preschool child, Pseudomonas aeruginosa, Pseudomonas infection, respiratory system, respiratory tract infection, Adolescent, Age Factors, Anti-Bacterial Agents, Bacteria, Child, Child, Preschool, Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator, Ecosystem, Genotype, Humans, Lung, Oropharynx, Pseudomonas aeruginosa, Pseudomonas Infections, Respiratory System, Respiratory Tract Infections, Bacteria (microorganisms), Pseudomonas aeruginosa },
    OWNER = { Luc },
    TIMESTAMP = { 2012.09.17 },
    URL = { http://www.scopus.com/inward/record.url?eid=2-s2.0-77953554827&partnerID=40&md5=7d7a8f0e2242c12674585e41bc9ad3d7 },
}

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