MacKayBoyleElEtAl2011

Référence

MacKay, J., Boyle, B., El Kayal, W., Namroud, M.-C., Doerksen, T., Cooke, J., Isabel, N., Beaulieu, J., Rigault, P., Bicho, P., Bousquet, J. (2011) Gene mapping in white spruce (P. glauca): QTL and association studies integrating population and expression data. BMC Proceedings, 5(Suppl 7):I6. (URL )

Résumé

Connecting phenotype with genotype is the basis for developing forest genetic applications such as marker assisted selection (MAS). Quantitative Trait Locus (QTL) mapping and genetic association mapping (or linkage disequilibrium (LD) are two major approaches to find genes that control phenotypes of interest in forest trees. Quantitative trait loci (QTL) and association mapping experiments in white spruce (Picea glauca [Moench] Voss) aimed to identify genes linked to or associated with growth, adaptation, and wood property traits. Gene mapping in conifer trees presents us with specific challenges, including very large genome sizes, low level of linkage disequilibrium, and large effective size in breeding populations. Therefore, association mapping experiments have relied on testing candidate gene targets rather than genome-wide association scans. We have explored different approaches to utilize gene expression and SNP outlier data to identify candidate genes, to help to explain the findings of gene mapping experiments and provide a broader understanding of observed phenotypic variations.

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@ARTICLE { MacKayBoyleElEtAl2011,
    AUTHOR = { MacKay, J. and Boyle, B. and El Kayal, W. and Namroud, M.-C. and Doerksen, T. and Cooke, J. and Isabel, N. and Beaulieu, J. and Rigault, P. and Bicho, P. and Bousquet, J. },
    TITLE = { Gene mapping in white spruce (P. glauca): QTL and association studies integrating population and expression data },
    JOURNAL = { BMC Proceedings },
    YEAR = { 2011 },
    VOLUME = { 5 },
    PAGES = { I6 },
    NUMBER = { Suppl 7 },
    ABSTRACT = { Connecting phenotype with genotype is the basis for developing forest genetic applications such as marker assisted selection (MAS). Quantitative Trait Locus (QTL) mapping and genetic association mapping (or linkage disequilibrium (LD) are two major approaches to find genes that control phenotypes of interest in forest trees. Quantitative trait loci (QTL) and association mapping experiments in white spruce (Picea glauca [Moench] Voss) aimed to identify genes linked to or associated with growth, adaptation, and wood property traits. Gene mapping in conifer trees presents us with specific challenges, including very large genome sizes, low level of linkage disequilibrium, and large effective size in breeding populations. Therefore, association mapping experiments have relied on testing candidate gene targets rather than genome-wide association scans. We have explored different approaches to utilize gene expression and SNP outlier data to identify candidate genes, to help to explain the findings of gene mapping experiments and provide a broader understanding of observed phenotypic variations. },
    DOI = { 10.1186/1753-6561-5-S7-I6 },
    ISSN = { 1753-6561 },
    OWNER = { amriv2 },
    URL = { http://www.biomedcentral.com/1753-6561/5/S7/I6 },
}

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