LamaraRaherisonLenzEtAl2016

Référence

Lamara, M., Raherison, E., Lenz, P., Beaulieu, J., Bousquet, J., MacKay, J. (2016) Genetic architecture of wood properties based on association analysis and co-expression networks in white spruce. New Phytologist, 210(1):240-255. (Scopus )

Résumé

Association studies are widely utilized to analyze complex traits but their ability to disclose genetic architectures is often limited by statistical constraints, and functional insights are usually minimal in nonmodel organisms like forest trees. We developed an approach to integrate association mapping results with co-expression networks. We tested single nucleotide polymorphisms (SNPs) in 2652 candidate genes for statistical associations with wood density, stiffness, microfibril angle and ring width in a population of 1694 white spruce trees (Picea glauca). Associations mapping identified 229-292 genes per wood trait using a statistical significance level of P < 0.05 to maximize discovery. Over-representation of genes associated for nearly all traits was found in a xylem preferential co-expression group developed in independent experiments. A xylem co-expression network was reconstructed with 180 wood associated genes and several known MYB and NAC regulators were identified as network hubs. The network revealed a link between the gene PgNAC8, wood stiffness and microfibril angle, as well as considerable within-season variation for both genetic control of wood traits and gene expression. Trait associations were distributed throughout the network suggesting complex interactions and pleiotropic effects. Our findings indicate that integration of association mapping and co-expression networks enhances our understanding of complex wood traits. © 2016 New Phytologist Trust.

Format EndNote

Vous pouvez importer cette référence dans EndNote.

Format BibTeX-CSV

Vous pouvez importer cette référence en format BibTeX-CSV.

Format BibTeX

Vous pouvez copier l'entrée BibTeX de cette référence ci-bas, ou l'importer directement dans un logiciel tel que JabRef .

@ARTICLE { LamaraRaherisonLenzEtAl2016,
    AUTHOR = { Lamara, M. and Raherison, E. and Lenz, P. and Beaulieu, J. and Bousquet, J. and MacKay, J. },
    TITLE = { Genetic architecture of wood properties based on association analysis and co-expression networks in white spruce },
    JOURNAL = { New Phytologist },
    YEAR = { 2016 },
    VOLUME = { 210 },
    PAGES = { 240-255 },
    NUMBER = { 1 },
    NOTE = { cited By 0 },
    ABSTRACT = { Association studies are widely utilized to analyze complex traits but their ability to disclose genetic architectures is often limited by statistical constraints, and functional insights are usually minimal in nonmodel organisms like forest trees. We developed an approach to integrate association mapping results with co-expression networks. We tested single nucleotide polymorphisms (SNPs) in 2652 candidate genes for statistical associations with wood density, stiffness, microfibril angle and ring width in a population of 1694 white spruce trees (Picea glauca). Associations mapping identified 229-292 genes per wood trait using a statistical significance level of P < 0.05 to maximize discovery. Over-representation of genes associated for nearly all traits was found in a xylem preferential co-expression group developed in independent experiments. A xylem co-expression network was reconstructed with 180 wood associated genes and several known MYB and NAC regulators were identified as network hubs. The network revealed a link between the gene PgNAC8, wood stiffness and microfibril angle, as well as considerable within-season variation for both genetic control of wood traits and gene expression. Trait associations were distributed throughout the network suggesting complex interactions and pleiotropic effects. Our findings indicate that integration of association mapping and co-expression networks enhances our understanding of complex wood traits. © 2016 New Phytologist Trust. },
    AUTHOR_KEYWORDS = { Association genetics; Co-expression network; Quantitative genetics; White spruce (Picea glauca); Wood traits },
    DOCUMENT_TYPE = { Article },
    DOI = { 10.1111/nph.13762 },
    KEYWORDS = { Picea glauca },
    SOURCE = { Scopus },
    URL = { http://www.scopus.com/inward/record.url?eid=2-s2.0-84959148040&partnerID=40&md5=ecc043261b5e44d7076ddf3e02c5709d },
}

********************************************************** *************************** FRQNT ************************ **********************************************************

Un regroupement stratégique du

********************************************************** ***************** Facebook Twitter *********************** **********************************************************

Abonnez-vous à
l'Infolettre du CEF!

********************************************************** ***************** Pub - ABC CBA 2020 ****************** **********************************************************

31 mai au 4 juin 2020

********************************************************** ***************** Pub - Symphonies_Boreales ****************** **********************************************************

********************************************************** ***************** Boîte à trucs *************** **********************************************************

CEF-Référence
La référence vedette !

Jérémie Alluard (2016) Les statistiques au moments de la rédaction 

  • Ce document a pour but de guider les étudiants à intégrer de manière appropriée une analyse statistique dans leur rapport de recherche.

Voir les autres...