GoldbergBennettKityoEtAl2017

Référence

Goldberg, T.L., Bennett, A.J., Kityo, R., Kuhn, J.H. and Chapman, C.A. (2017) Kanyawara Virus: A Novel Rhabdovirus Infecting Newly Discovered Nycteribiid Bat Flies Infesting Previously Unknown Pteropodid Bats in Uganda. Scientific Reports, 7(1). (Scopus )

Résumé

Bats are natural reservoir hosts of highly virulent pathogens such as Marburg virus, Nipah virus, and SARS coronavirus. However, little is known about the role of bat ectoparasites in transmitting and maintaining such viruses. The intricate relationship between bats and their ectoparasites suggests that ectoparasites might serve as viral vectors, but evidence to date is scant. Bat flies, in particular, are highly specialized obligate hematophagous ectoparasites that incidentally bite humans. Using next-generation sequencing, we discovered a novel ledantevirus (mononegaviral family Rhabdoviridae, genus Ledantevirus) in nycteribiid bat flies infesting pteropodid bats in western Uganda. Mitochondrial DNA analyses revealed that both the bat flies and their bat hosts belong to putative new species. The coding-complete genome of the new virus, named Kanyawara virus (KYAV), is only distantly related to that of its closest known relative, Mount Elgon bat virus, and was found at high titers in bat flies but not in blood or on mucosal surfaces of host bats. Viral genome analysis indicates unusually low CpG dinucleotide depletion in KYAV compared to other ledanteviruses and rhabdovirus groups, with KYAV displaying values similar to rhabdoviruses of arthropods. Our findings highlight the possibility of a yet-to-be-discovered diversity of potentially pathogenic viruses in bat ectoparasites. © 2017 The Author(s).

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@ARTICLE { GoldbergBennettKityoEtAl2017,
    AUTHOR = { Goldberg, T.L. and Bennett, A.J. and Kityo, R. and Kuhn, J.H. and Chapman, C.A. },
    TITLE = { Kanyawara Virus: A Novel Rhabdovirus Infecting Newly Discovered Nycteribiid Bat Flies Infesting Previously Unknown Pteropodid Bats in Uganda },
    JOURNAL = { Scientific Reports },
    YEAR = { 2017 },
    VOLUME = { 7 },
    NUMBER = { 1 },
    NOTE = { cited By 0 },
    ABSTRACT = { Bats are natural reservoir hosts of highly virulent pathogens such as Marburg virus, Nipah virus, and SARS coronavirus. However, little is known about the role of bat ectoparasites in transmitting and maintaining such viruses. The intricate relationship between bats and their ectoparasites suggests that ectoparasites might serve as viral vectors, but evidence to date is scant. Bat flies, in particular, are highly specialized obligate hematophagous ectoparasites that incidentally bite humans. Using next-generation sequencing, we discovered a novel ledantevirus (mononegaviral family Rhabdoviridae, genus Ledantevirus) in nycteribiid bat flies infesting pteropodid bats in western Uganda. Mitochondrial DNA analyses revealed that both the bat flies and their bat hosts belong to putative new species. The coding-complete genome of the new virus, named Kanyawara virus (KYAV), is only distantly related to that of its closest known relative, Mount Elgon bat virus, and was found at high titers in bat flies but not in blood or on mucosal surfaces of host bats. Viral genome analysis indicates unusually low CpG dinucleotide depletion in KYAV compared to other ledanteviruses and rhabdovirus groups, with KYAV displaying values similar to rhabdoviruses of arthropods. Our findings highlight the possibility of a yet-to-be-discovered diversity of potentially pathogenic viruses in bat ectoparasites. © 2017 The Author(s). },
    AFFILIATION = { Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, United States; Global Health Institute, University of Wisconsin-Madison, Madison, WI, United States; Department of Zoology, Makerere University, Kampala, Uganda; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States; Department of Anthropology and School of Environment, McGill University, Montreal, QC, Canada },
    ART_NUMBER = { 5287 },
    DOCUMENT_TYPE = { Article },
    DOI = { 10.1038/s41598-017-05236-w },
    SOURCE = { Scopus },
    URL = { https://www.scopus.com/inward/record.uri?eid=2-s2.0-85023758575&doi=10.1038%2fs41598-017-05236-w&partnerID=40&md5=a89cda22bb276314f432d137b64b08ea },
}

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